π€ Authors:Degenhardt Sarah, Bender Marc, Chen I-Peng+ 8 more
π Abstract:
Melanoma treatment has improved significantly with the development of immune checkpoint inhibition (ICI), which has greatly enhanced the survival rates of patients with metastatic melanoma. However, a significant number of pat...
π€ Authors:Oluwafemi Oyamakin S., U. Chukwu Angela, Oluwaseun A Wale-Orojo+ 1 more
π Abstract:
In other to present a series of stochastic models from population dynamics capable of describing rudimentary aspects of genetic evolution, we studied two-allele WrightβFisher and the Moran models for evolution of the relative frequencies of ...
π€ Authors:Abdolkazem Neisi, Parviz Mahmoudi, Neda Kayedi+ 1 more
π Abstract:
Benzene is known as an environmental and industrial pollutant. One way to check the amount of exposure to benzene is to measure its metabolites in the urine. Trans, Trans-Muconic Acid which is one of its metabolites is also as a biological i...
Introduction
Genomic mutations in TP53 gene in association with etiological risk factors have been associated with oral carcinogenesis. Herein, we screened for genomic variants of TP53 predisposing to oral...
Upon considering the anticancer effects of larger oligomeric proanthocyanidins and observing various papers reporting the high resolution mass spectroscopy of the oligomeric proanthocyanidins, it is determined that the unusual 13C enrichment...
π€ Authors:Zhang Xi, Wang Yan, Ouyang Qin+ 1 more
π Abstract:
As remarkable advances have been made in immunotherapies, the overall goal of immunotherapy has become the selection of patients and evaluating the benefits of treatment. One of the major obstacles to develop immunotherapies is the lack of e...
π€ Authors:L. Clark Jennifer, Lee Connie, Kandil Dina+ 2 more
π Abstract:
We report the case of a 75 year-old female with past history of ampullary adenocarcinoma presenting with a rapidly enlarging breast mass, initially misclassified on fine needle aspiration as a probable sarcoma, which was ultimately diagnosed...
π€ Authors:Gupta Shilpi, Kumar Prabhat, Maini Jayant+ 1 more
π Abstract:
Head and Neck cancer (HNC) is one of the most prevalent and lethal cancer globally. The incidence of tobacco-induced HNC is gradually increasing in low and middle income countries. Among the various causative factors associated with HNCs, to...
This review revisits alphaβfetoprotein (AFP) and AFP receptor biology beyond their classic role as oncofetal markers. It summarizes signaling, tumor biology, and clinical implications across malignancies, including diagnostic, prognostic, an...
π€ Authors:Morales Rafael, Serrano Raquel, SardΓ³n Teresa+ 4 more
π Abstract:
Interpreting variants of uncertain significance (VUS) for their effect on protein function, and therefore for the risk of developing cancer, has become a challenge in clinical practice for genetic counselling services. The present work combi...
π€ Authors:A. E Adetona, G. O Ogun, C. A. Okolo+ 1 more
π Abstract:
Objective
P16INK4a and Ki-67 are adjuncts to current histological assessment of cervical biopsies in identifying cases that require strict follow up and prompt intervention. This study aimed to evaluate P16INK4a and Ki-6...
π€ Authors:Maurer Adrian, Archer Jacob, Safavi-Abbasi Sam+ 1 more
π Abstract:
Meningiomas are the most common intracranial tumor in humans. The heterogeneity of these tumors lends difficulty to the genetic, epigenetic, and molecular changes that occur in meningioma pathogenesis, progression, and recurrence. Current de...
This paper reviews the state of cancer research in the post-mutation era. It presents cancer as a highly complex disease viewed differently by scientists from various research fields. Histopathologists considered cancer as a disease of cell ...
π€ Authors:Gupta Shilpi, Kumar Prabhat, Maini Jayant+ 2 more
π Abstract:
Head and neck cancers (HNCs) are the most prevalent and aggressive type of cancers. Genetic, epigenetic, environmental and viral risk-factors are associated with HNC carcinogenesis. Persistent infection of oncogenic human papillomaviruses (H...
Objective:
To utilize the effectiveness of MR-Enterography as a potential investigating marker for the diagnosis of Crohnβs disease.
Conclusion:
This article reviews the technique of...
π€ Authors:P Menon Madhu, Schattgen Stefan, Tadiri Sarah+ 1 more
π Abstract:
Thyroid carcinomas encompass a wide spectrum ranging from differentiated thyroid carcinoma (DTC) to poorly differentiated (PDC) and anaplastic thyroid carcinoma (ATC). DTC of both follicular (FTC) and papillary (PTC) types can progress to PD...
π€ Authors:Hayashi Takuma, Ichimura Tomoyuki, Ando Hirofumi+ 8 more
π Abstract:
Human uterine leiomyosarcoma (LMS) is neoplastic malignancy that typically arises in tissues of mesenchymal origin. The identification of novel molecular mechanism leading to human uterine LMS formation and the establishment of new therapies...
π€ Authors:omer Ibtihal, salahddin Dalia, Hussein Musa Hassan+ 2 more
π Abstract:
Background:
Gastric cancer (GC) ranks as the fourth most common cancer and the second leading cause of cancer deaths worldwide. Epstein-Barr virus is a well-known oncogenic virus, it is responsible for 10% of gastric car...
Investigation of Antimicrobial Activity of the Extracts of the Leaves, Stembark and Root of Allanblackia floribunda: An Alternative Paradigm Shift Outcome.
Liaquat University of Medical and Health Sciences Jamshoro
Ashique Ali Arain, Syed Muhammad Ali, Madiha Shah
Vitamin -D Deficiency: A Clinical Problem Searching For Solution.